Cytidine-5'-diphosphocholine affects CTP-phosphocholine cytidylyltransferase and lyso-phosphatidylcholine after transient brain ischemia.
作者： Rao Muralikrishna Adibhatla , James F. Hatcher , Robert J. Dempsey
DOI: 10.1002/JNR.20078
关键词:
摘要: Cytidine-5-diphosphocholine (CDP-choline, also referred as citicoline), the key intermediate in phosphatidylcholine (PtdCho) synthesis, provided significant benefit experimental central nervous system (CNS) injury including cerebral ischemia. CDP-choline is synthesized by CTP:phosphocholine cytidylyltransferase (CCT), rate-limiting enzyme PtdCho synthesis. Phospholipase A2 (PLA2) hydrolyzes to produce free fatty acids and lyso-PtdCho, an inhibitor of CCT. We investigated status CCT lyso-PtdCho after 10-min transient brain ischemia gerbils with reperfusion up 2 days. Ischemia no resulted loss activity cytosol (408 8 pmol/min/mg protein
sci-hub.se 参考文章(49)
Andrei Alexandrov, Citicoline. Ferrer Internacional. Current opinion in investigational drugs. ,vol. 2, pp. 1757- 1762 ,(2001)
Y. Wang, T.D. Sweitzer, P.A. Weinhold, C. Kent, Nuclear localization of soluble CTP:phosphocholine cytidylyltransferase. Journal of Biological Chemistry. ,vol. 268, pp. 5899- 5904 ,(1993) , 10.1016/S0021-9258(18)53405-0
A. Muralikrishna Rao, J. F. Hatcher, R. J. Dempsey, Lipid alterations in transient forebrain ischemia: possible new mechanisms of CDP-choline neuroprotection. Journal of Neurochemistry. ,vol. 75, pp. 2528- 2535 ,(2008) , 10.1046/J.1471-4159.2000.0752528.X
Paul A. Weinhold, Douglas A. Feldman, [29] Choline-phosphate cytidylyltransferase Phospholipid Biosynthesis. ,vol. 209, pp. 248- 258 ,(1992) , 10.1016/0076-6879(92)09031-W
Hiroyuki Kinouchi, Shigeki Imaizumi, Takashi Yoshimoto, Hirotaka Yamamoto, Masakichi Motomiya, Changes of polyphosphoinositides, lysophospholipid, and free fatty acids in transient cerebral ischemia of rat brain. Molecular and Chemical Neuropathology. ,vol. 12, pp. 215- 228 ,(1990) , 10.1007/BF03159946
Wataru Araki, Richard J. Wurtman, How is membrane phospholipid biosynthesis controlled in neural tissues Journal of Neuroscience Research. ,vol. 51, pp. 667- 674 ,(1998) , 10.1002/(SICI)1097-4547(19980315)51:6<667::AID-JNR1>3.0.CO;2-9
W. Araki, R. J. Wurtman, Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 11946- 11950 ,(1997) , 10.1073/PNAS.94.22.11946
Joel M. Clement, Claudia Kent, CTP:phosphocholine cytidylyltransferase: insights into regulatory mechanisms and novel functions. Biochemical and Biophysical Research Communications. ,vol. 257, pp. 643- 650 ,(1999) , 10.1006/BBRC.1999.0512
Lloyd A. Horrocks, Robert V. Dorman, Zbigniew Dabrowiecki, Gianfrancesco Goracci, Giuseppe Porcellati, CDPcholine and CDpethanolamine prevent the release of free fatty acids during brain ischemia Progress in Lipid Research. ,vol. 20, pp. 531- 534 ,(1981) , 10.1016/0163-7827(81)90093-X
Kevin P. Boggs, Charles O. Rock, Suzanne Jackowski, Lysophosphatidylcholine and 1-O-Octadecyl-2-O-Methyl-rac- Glycero-3-Phosphocholine Inhibit the CDP-Choline Pathway of Phosphatidylcholine Synthesis at the CTP:Phosphocholine Cytidylyltransferase Step Journal of Biological Chemistry. ,vol. 270, pp. 7757- 7764 ,(1995) , 10.1074/JBC.270.13.7757