Changes of polyphosphoinositides, lysophospholipid, and free fatty acids in transient cerebral ischemia of rat brain.
作者： Hiroyuki Kinouchi , Shigeki Imaizumi , Takashi Yoshimoto , Hirotaka Yamamoto , Masakichi Motomiya
DOI: 10.1007/BF03159946
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摘要: Phosphatidylinositol (PI), phosphatidylinositol 4-phosphate (PIP), 4, 5-bisphosphate (PIP2), 1, 2-diglyceride (DG), lysophosphatidylcholine (LPC), and free fatty acids (FFA) contents, as well their acid composition, were measured in transient global cerebral ischemia. ATP CTP also studied. Male Wistar rats subjected to 5, 30 min of ischemia 10, 30, 60 recirculation following In addition, for the quantification PI, PIP, PIP2, 5 PIP2 PIP decreased rapidly during recovered completely after recirculation. DG increased almost at same rate returned normal PI showed no changes throughout entire course. LPC Stearic arachidonic contained ischemia, whereas saturated LPC. Among FFA accumulated stearic followed by increases other FFA. From these results, pathways increase fate are discussed. importance is
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