IL-1 beta does not cause neutrophil degranulation but does lead to IL-6, IL-8, and nitrite/nitrate release when used in patients with cancer.

摘要: The use of IL-1 in humans is associated with dose-limiting toxicity which resembles that TNF-alpha or IL-2. Activation neutrophils thought to contribute the caused by these two cytokines. We studied effect vivo on changes neutrophil numbers and degranulation as well formation agonists, such complement activation products, levels TNF, IL-6, IL-8, nitrite/nitrate (as a measure nitric oxide production). Six patients metastatic melanoma were treated 3 ng/kg recombinant human beta daily. One hour after start 30-min infusion, mild cardiovascular toxicity, plasma IL-6 reached peak 25 +/- 9 ng/L (mean SEM), IL-8 311 100 at 2 h, peaked 10 h 89 27 mumol/L. did not induce significant TNF products C3a C4b/c. Although induced neutrophilia, elastase lactoferrin change. failure degranulate was confirmed an ex model whole blood culture doses up microgram/L alpha failed release, whereas tested positive control, able do so. These results demonstrate that, unlike does cause man, despite its ability neutrophilia rapid release nitrite/nitrate.