Toxicity and therapeutic activity of tyrothricin by oral administration.

摘要: SummaryThe maximum tolerated dose of tyrothricin for adult white mice, administered by stomach tube 3 times a day 10 days in succession, was about 0.0008 g per mouse. By this route administration doses daily 0.0004 mouse were very slightly effective the treatment mice inoculated with virulent Streptococcus hemolyticus (group A) and type III pneumococcus, while definitely more types I II pneumococci especially I. Tyrothricin 0.0002, 0.001 0.002 kg, 15 completely ineffective acute testicular syphilis rabbits.