Blood Concentration of Coenzyme Q10 Increases in Rats When Esterified Forms Are Administered

摘要: Coenzyme Q levels decrease during aging in most tissues and the target organs of a number diseases. The uptake this lipid into blood other was investigated 6-wk-old male Sprague-Dawley rats after 3 wk dietary supplementation. In addition to natural form coenzyme Q(10), acetylated succinylated forms were also administered. Q(10) taken up blood, but significantly greater given ( approximately 40%), particularly, 70%). All three increased total concentration both liver 100%) spleen 130%). its esterified not kidney, heart, muscle or brain. Intraportal intraperitoneal administration gave results similar those obtained experiments. Uptake did down-regulate endogenous synthesis, i.e., amounts isolated Q(9) change these tissues. Thus, esterification increases blood; however, derivatization does contribute elevation various organs.