HIV drug development: the next 25 years

摘要: The development of drugs for HIV infection began soon after the virus was discovered 25 years ago. Since then, progress has been substantial, but numerous uncertainties persist about best way to manage this disease. Here we review current treatment options, consider novel mechanisms that can be exploited existing drug targets, and explore potential targets. With a view next quarter century, whether resistance avoided, which classes will favoured over others, strategies are most likely succeed, impact pharmacogenomics individualized therapy.