Selection of parameters for thermal coronavirus inactivation - a data-based recommendation

摘要: Background: Healthcare workers and large parts of the population are currently using personal protective equipment, such as face masks, to avoid infections with novel coronavirus SARS-CoV-2. This equipment must be sterilized gently possible before reuse. One possibility is thermal inactivation, but professional autoclaves their high temperatures often not available or suitable. If inactivation period long enough, can also carried out at relatively low temperatures. The required duration was determined in this study. Material methods: Data from published studies on coronaviruses were applied determine temperature dependence rate constant k(T) for each by employing Arrhenius models. Results: data obtained exhibit variations, which appear least partially caused different sample properties. Samples protein content samples dry air sometimes seem more difficult inactivate. Apart this, models describe properties well SARS-CoV SARS-CoV-2 even represented a combined model. Furthermore, suggest that all samples, including critical ones, mathematically included worst-case Conclusion: Coronaviruses already inactivated For most application times approximately 32.5, 3.7, 0.5 minutes will sufficient 60°C, 80°C, 100°C, respectively, 5 log-reduction. conditions, model provides significantly longer 490, 55, 8 mentioned.