Oral Acyclovir for Prevention of Herpes Simplex Virus Reactivation After Marrow Transplantation
作者： JAMES C WADE , BARBARA NEWTON , NANCY FLOURNOY , JOEL D MEYERS
DOI: 10.7326/0003-4819-100-6-823
关键词: Herpes simplex virus 、 Aciclovir 、 Viral disease 、 Medicine 、 Gastroenterology 、 Immunology 、 Virus 、 Methotrexate 、 Placebo 、 Transplantation 、 Internal medicine 、 Oral administration 、 General Medicine
摘要: Oral acyclovir was found to be safe and effective for the prevention of herpes simplex virus reactivation after marrow transplantation in a double-blind, placebo-controlled trial. Acyclovir or placebo administered 49 patients 5 weeks beginning 1 week before transplantation: 24 receiving developed infection during prophylaxis, compared 17 25 (p less than 0.01). The median time first significantly longer among (78 days versus 9 transplant, p = 0.006). effect even more pronounced when analysis adjusted drug compliance: Among taking minimum 40% their prescribed drug, 96% virologically 100% clinically period administration. use also associated with rapid engraftment methotrexate. No resistant isolated. provides prophylaxis against severely immunosuppressed able take orally drugs.
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