Prophylactic acyclovir effectively reduces herpes simplex virus type 1 reactivation after exposure of latently infected mice to ultraviolet B.

摘要: PURPOSE: To determine the potential efficacy and anatomic sites of action prophylactic oral acyclovir using a murine model ultraviolet-B-induced reactivation herpes simplex 1 keratitis. METHODS: Latent infection with (McKrae) was established in 80 National Institutes Health inbred strain mice. Forty mice were given orally other 40 latently infected served as controls. Mice exposed to 250 mJ/cm2 ultraviolet-B radiation killed on days 1, 2, 3, 4 after radiation. Trigeminal ganglia eyes from these homogenized incubated Vero cell monolayers for recovery reactivated virus. RESULTS: Based infectious virus treated versus control groups, effectively reduced detectable viral at both ocular level (P = 0.003) ganglionic 0.025). The numbers culture-positive eye trigeminal homogenates group 11 6 out 40, respectively, compared 0 Therapeutic serum levels confirmed by high performance liquid chromatography. In acyclovir-tested group, single case break-through surface not an acyclovir-resistant mutant. CONCLUSION: Prophylactic reduces incidence virus-1