Metacognitive training for schizophrenia: a systematic review.

摘要: BACKGROUND: Metacognitive training (MCT) is a novel group psychotherapy method for schizophrenia, but there is, as yet, no conclusive evidence of its efficacy. AIMS: Conduct meta-analysis to assess the effectiveness MCT in schizophrenia. METHODS: Electronic and hand searches were conducted identify randomized controlled trials about effects schizophrenia that met pre-defined inclusion criteria. The Cochrane Risk Bias tool was employed risk biases, Review Manager version 5.3 R 3.1.1 used conduct data synthesis. RESULTS: Ten from 54 unduplicated reports included review, differences methods assessing outcomes limited number studies could be meta-analysis. Pooling four assessed positive symptom subscale Positive Negative Syndrome Scale (PANSS) at end trial identified small statistically significant greater reduction than control group. But pooling delusion Psychotic Symptom Rating Scales (PSYRATS) found difference between groups. Results qualitative assessment other results not pooled across mixed, some showed trend favor many groups. CONCLUSIONS: RCT trials, variability time outcome evaluation, methodological problems make it impossible come conclusion schizophrenia. More use standardized measures, intention-to-treat (ITT) analyses, follow-up participants regular intervals after intervention are needed determine whether or should become recommended adjunctive treatment