Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility.

摘要: DNA fragmentation is an important factor in the aetiology of male infertility. However, it still underevaluated and its inclusion routine semen analysis debated. has been shown to be a robust indicator fertility potential, more so than conventional parameters. Men with high levels have significantly lower odds conceiving, naturally or through procedures such as intrauterine insemination IVF. Couples may counselled proceed directly intracytoplasmic sperm injection successful this group, avoiding costly procedures, recurrent failures pregnancy losses; however, treatment not without limitations risks. Ideally should minimized where possible. Oxidative stress major cause spermatozoa. Endogenous exogenous factors that contribute oxidative are discussed, many cases easily modifiable. Antioxidants play protective role, although delicate balance reduction oxidation required for essential functions, including fertilization. Reducing improve couple's chances conception either via assisted reproduction. Sources therefore thoroughly examined men modified However will conceiving Intracytoplasmic (ICSI) much couples ICSI, losses. ICSI Ideally, investigated possible trying conceive reproduction technology. discussed function, treatment.