Bisphenol A, oocyte maturation, implantation, and IVF outcome: review of animal and human data

摘要: Recent data have raised concerns about the detrimental effect of chronic exposure to environmental chemicals. Some chemicals affect endocrine system (endocrine disruptors) and been linked several diseases, including infertility. One such disruptor is bisphenol A (BPA), a monomer widely used in plastic industry, with nearly ubiquitous exposure. In this review, on effects BPA female fertility are summarized. Specifically, its considered folliculogenesis, oocyte maturation, embryo quality, implantation, both animal human models. Animal studies shown that might impair prophase I, follicular growth, may be associated spindle abnormalities. humans, while in-vitro suggested an association between impaired meiosis, clinical evidence indicate possible adverse IVF outcomes. As still scarce, larger required further elucidate fertility.