Prophylactic immunotherapy of Alzheimer's disease using recombinant amyloid-β B-cell epitope chimeric protein as subunit vaccine.

摘要: Alzheimer's disease (AD) is a neurodegenerative disorder that impairs memory and cognition. The neuropathological features of the include senile plaques (SPs), neurofibrillary tangles (NFTs) neuronal loss in affected brain regions. amyloid cascade hypothesis suggests production accumulation excessive amyloid-β (Aβ) may be main cause onset progression disease. Active passive immunotherapy targeting Aβ most promising strategy to prevent or treat AD. This commentary focuses on prophylactic using recombinant B-cell epitope chimeric protein as subunit vaccine amyloid-β. We discuss efficiency perspective this type suggest novel direction path successful AD immunotherapy. immunogen designed mimic assembly states Aβ42 oligomers multivalent foldable Aβ1-15 (B cell epitopes Aβ42) foreign T helper (Th) (as constructs.