Amyloid-β Peptide Remnants in AN-1792-Immunized Alzheimer's Disease Patients: A Biochemical Analysis

摘要: Experiments with amyloid-β (Aβ)-42-immunized transgenic mouse models of Alzheimer's disease have revealed amyloid plaque disruption and apparent cognitive function recovery. Neuropathological examination patients vaccinated against purified Aβ-42 (AN-1792) has demonstrated that senile occurred in immunized humans as well. Here, we examined tissue histology quantified biochemically characterized the remnant peptides gray white matter leptomeningeal/cortical vessels two AN-1792-vaccinated patients, one whom developed meningoencephalitis. Compact core diffuse deposits both individuals were focally absent some regions. Although parenchymal was disaggregated, vascular relatively preserved or even increased. Immunoassay total soluble levels sharply elevated patient compared cases. Our experiments suggest although immunization disrupted deposits, capture prevented large-scale egress Aβ peptides. Trapped, solubilized may ultimately cascading toxic effects on cerebrovascular, tissues. Anti-amyloid be most effective not therapeutic mitigating measures but a prophylactic measure when deposition is still minimal. This allow mobilization under conditions which drainage degradation these efficient.