Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid β from the human brain

摘要: Accumulation of amyloid beta (Abeta) in the extracellular spaces cerebral cortex and blood vessel walls as angiopathy is a characteristic Alzheimer's disease (AD) ageing human brain. Studies animals suggest that Abeta eliminated from brain either directly into or along perivascular interstitial fluid drainage channels. The aim present study to define route for Smears paraffin sections post-mortem cortical tissue 17 cases AD two controls were stained with thioflavin by immunohistochemistry. Histology confocal microscopy showed deposits parenchyma continuous capillary but artery was not continuity parenchyma. Quantitative studies supported these observations. results this when route, it enters pericapillary there drains arteries leptomeningeal arteries. Factors such overproduction Abeta, entrapment pathways poor due functional changes might result failure elimination play major role pathogenesis AD. Such factors affect therapies entail administration anti-Abeta antibodies eliminate