Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy

摘要: Deposition of amyloid β (Aβ) in the walls cerebral arteries as angiopathy (CAA) suggests an age-related failure perivascular drainage soluble Aβ from brain. As CAA is associated with Alzheimer's disease and intracerebral haemorrhage, present study determines unique sequence changes that occur accumulates artery walls. Paraffin sections post-mortem human occipital cortex were immunostained for collagen IV, fibronectin, nidogen 2, smooth muscle actin immunostaining was analysed using Image J confocal microscopy. Results showed 2 (entactin) increases age decreases CAA. Confocal microscopy revealed stages progression CAA: initially deposits basement membranes tunica media, replaces first cells then connective tissue elements to leave completely or focally replaced by Aβ. The pattern development brain expansion progressively replace all wall. Establishing this full picture pivotal understanding clinical presentation developing therapies prevent accumulation This article part a Special Issue entitled: Vascular Contributions Cognitive Impairment Dementia edited M. Paul Murphy, Roderick A. Corriveau Donna Wilcock.