Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease. Pro-CAA position statement.

作者: James A.R. Nicoll , Masahito Yamada , Janusz Frackowiak , Bozena Mazur-Kolecka , Roy O. Weller

DOI: 10.1016/J.NEUROBIOLAGING.2004.02.003

关键词:

摘要: … CAA) has a direct role in the pathogenesis of Alzheimer’s disease (AD). Firstly, there is a very close relationship between CAA … accumulation of Aβ as CAA. Reduced elimination leads to …

参考文章(59)
Melchor Jp, Van Nostrand We, Disruption of pathologic amyloid beta-protein fibril assembly on the surface of cultured human cerebrovascular smooth muscle cells. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. pp. 20- ,(2001)
Related Disorders, Khalid Iqbal, Research advances in Alzheimer's disease and related disorders : Wiley. ,(1995)
Yu-Min Kuo, Thomas G. Beach, Lucia I. Sue, Sarah Scott, Kathryn J. Layne, Tyler A. Kokjohn, Walter M. Kalback, Dean C. Luehrs, Tatiana A. Vishnivetskaya, Dorothee Abramowski, Christine Sturchler-Pierrat, Matthias Staufenbiel, Roy O. Weller, Alex E. Roher, The Evolution of Aβ Peptide Burden in the APP23 Transgenic Mice: Implications for Aβ Deposition in Alzheimer Disease Molecular Medicine. ,vol. 7, pp. 609- 618 ,(2001) , 10.1007/BF03401867
Brian J. Bacskai, Stephen T. Kajdasz, Richard H. Christie, Cordelia Carter, Dora Games, Peter Seubert, Dale Schenk, Bradley T. Hyman, Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nature Medicine. ,vol. 7, pp. 369- 372 ,(2001) , 10.1038/85525
S. D. Preston, P. V. Steart, A. Wilkinson, J. A. R. Nicoll, R. O. Weller, Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid β from the human brain Neuropathology and Applied Neurobiology. ,vol. 29, pp. 106- 117 ,(2003) , 10.1046/J.1365-2990.2003.00424.X
P. Hedera, R. P. Friedland, D. R. D. Premkumar, R. N. Kalaria, D. L. Cohen, Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. American Journal of Pathology. ,vol. 148, pp. 2083- 2095 ,(1996)
I. Otte-Höller, P. Wesseling, D. J. Ruiter, M. M. Verbeek, R. M. W. De Waal, Induction of alpha-smooth muscle actin expression in cultured human brain pericytes by transforming growth factor-beta 1. American Journal of Pathology. ,vol. 144, pp. 372- 382 ,(1994)
Roy O. Weller, Adrian Massey, Tracey A. Newman, Margaret Hutchings, Yu-Min Kuo, Alex E. Roher, Cerebral Amyloid Angiopathy The American Journal of Pathology. ,vol. 153, pp. 725- 733 ,(1998) , 10.1016/S0002-9440(10)65616-7
G. Taubes, Insulin Insults May Spur Alzheimer's Disease Science. ,vol. 301, pp. 40- 41 ,(2003) , 10.1126/SCIENCE.301.5629.40
Dale Schenk, Robin Barbour, Whitney Dunn, Grace Gordon, Henry Grajeda, Teresa Guido, Kang Hu, Jiping Huang, Kelly Johnson-Wood, Karen Khan, Dora Kholodenko, Mike Lee, Zhenmei Liao, Ivan Lieberburg, Ruth Motter, Linda Mutter, Ferdie Soriano, George Shopp, Nicki Vasquez, Christopher Vandevert, Shannan Walker, Mark Wogulis, Ted Yednock, Dora Games, Peter Seubert, Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. ,vol. 400, pp. 173- 177 ,(1999) , 10.1038/22124