Binding affinity of thermoresponsive polyelectrolyte hydrogels for charged amphiphilic ligands. A DSC approach.

摘要: Controlled drug binding and release stand among top requirements postulated for targeted delivery systems of the new generations. "Smart" polymers gels are highly suitable controlled due to their structural sensitivity minor environmental variations. The aim this work was study thermoresponsive polyanionic polycationic hydrogels N-isopropylacrylamide copolymers with acrylic acid N-aminopropylmethacrylamide in terms interaction two widely used drugs, propranolol ibuprofen. Binding energetics these drugs by swollen collapsed state estimated means high-sensitivity differential scanning calorimetry. Thermodynamic parameters gel collapse (transition temperature, enthalpy, heat capacity increment, width) were determined as a dependence concentrations. From data excess free energy calculated function concentration. Deconvolution resulted evaluation contributions from interactions various types binding. mechanism both elucidated. Its main features cooperative character predominant role hydrophobicity affinity gel.