The gero-inflammatory manifold

摘要: Inflammatory processes during Alzheimer’s disease (AD) may be considered as part of a larger manifold oxidative and inflammatory that slowly develop aging in many tissue beds throughout the organism well brain. Other chapters this volume have described cellular molecular interactions between aggregates amyloid β-peptide (Aβ) system components. In considering whether are primary or secondary AD aging, we discuss evidence associated with formation tissues. We also point out similarities differences brain changes humans various laboratory models. Moreover, some experimental clinical interventions non-neural tissues work by modulating through systemic physiological factors. Thus, could context age-related pathobiology which designate gero-inflammatory (Fig. 1).