Neurons, glia, and plasticity in normal brain aging.
作者： Caleb E. Finch
DOI: 10.1016/S0197-4580(03)00051-4
关键词:
摘要: Early manifestations of brain aging have received much less attention than the drastic degeneration AD and MID. During nonpathological changes normal aging, systems differ in involvement neuron loss. Spatial learning can become impaired without evidence for loss, whereas eye-blink conditioning deficits are well correlated with Purkinje Glial activation, particular increased expression glial fibrillary acidic protein (GFAP), may be a factor synaptic plasticity. Lastly, it is discussed how developmental variations numbers cells ovarian oocytes factors outcomes that not under strict genetic control.
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sci-hub.se 参考文章(50)
Caleb E. Finch, Valter D. Longo, The gero-inflammatory manifold Birkhäuser, Basel. pp. 237- 256 ,(2001) , 10.1007/978-3-0348-8350-4_13
Véronique Menet, Minerva Giménez y Ribotta, Norbert Chauvet, Marie Jeanne Drian, Julie Lannoy, Emma Colucci-Guyon, Alain Privat, Inactivation of the glial fibrillary acidic protein gene, but not that of vimentin, improves neuronal survival and neurite growth by modifying adhesion molecule expression. The Journal of Neuroscience. ,vol. 21, pp. 6147- 6158 ,(2001) , 10.1523/JNEUROSCI.21-16-06147.2001
AF Arnsten, JX Cai, JC Steere, PS Goldman-Rakic, Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys The Journal of Neuroscience. ,vol. 15, pp. 3429- 3439 ,(1995) , 10.1523/JNEUROSCI.15-05-03429.1995
B Stein-Behrens, MP Mattson, I Chang, M Yeh, R Sapolsky, Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus The Journal of Neuroscience. ,vol. 14, pp. 5373- 5380 ,(1994) , 10.1523/JNEUROSCI.14-09-05373.1994
T.E Morgan, Z Xie, S Goldsmith, T Yoshida, A.-S Lanzrein, D Stone, I Rozovsky, G Perry, M.A Smith, C.E Finch, The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction. Neuroscience. ,vol. 89, pp. 687- 699 ,(1999) , 10.1016/S0306-4522(98)00334-0
Todd E Morgan, Irina Rozovsky, Sarah K Goldsmith, David J Stone, Toru Yoshida, Caleb E Finch, Increased transcription of the astrocyte gene GFAP during middle-age is attenuated by food restriction: implications for the role of oxidative stress. Free Radical Biology and Medicine. ,vol. 23, pp. 524- 528 ,(1997) , 10.1016/S0891-5849(97)00120-2
James R. Goss, Caleb E. Finch, David G. Morgan, Age-related changes in glial fibrillary acidic protein mRNA in the mouse brain. Neurobiology of Aging. ,vol. 12, pp. 165- 170 ,(1991) , 10.1016/0197-4580(91)90056-P
Diana S. Woodruff-Pak, Judith F. Cronholm, Joel B. Sheffield, Purkinje cell number related to rate of classical conditioning. Neuroreport. ,vol. 1, pp. 165- 168 ,(1990) , 10.1097/00001756-199010000-00020
R. S. Sohal, R. Weindruch, Oxidative Stress, Caloric Restriction, and Aging Science. ,vol. 273, pp. 59- 63 ,(1996) , 10.1126/SCIENCE.273.5271.59
C. Finch, M. Pike, M Witten, Slow mortality rate accelerations during aging in some animals approximate that of humans. Science. ,vol. 249, pp. 902- 905 ,(1990) , 10.1126/SCIENCE.2392680