Receptors for the TGF-beta ligand family.

摘要: Publisher Summary This chapter summarizes the current status of research in transforming growth factor-β (TGF-β) receptor field. The TGF-β is a group multi-functional peptide hormones that regulate many aspects cellular function. identified as protein induced normal rat kidney fibroblasts to proliferate soft agar presence epidermal factor (EGF). can inhibit differentiation certain mesodermal cells, induce others, and proliferation cells derived from epithelial, endothlial, neuronal, hematopoietic, lymphoid, fibroblastic origins. effects on individual also important biological processes. an regulator immune responses, wound healing, cell adhesion, cell-cell recognition, extracellular matrix deposition. Deregulation function implicated pathological processes several diseases including arthritis, atheosclerosis, glomerulonephritis. lose ability respond may exhibit uncontrolled become tumorigenic. receptors transduce signals result TGF-β-induced gene responses inhibition. type I, II, III receptors, are focused they widely expressed most biologically relevant mediators signal transduction.