Novel synthetic analogs of sphingolipids

作者: Shimon Slavin , Jeremy Zahavi , Arieh Dagan , Shimon Gatt

DOI:

关键词: StereochemistryCeramideCellBiochemistryChemistrySphingolipid

摘要: The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel exhibit a significant anti cancerous effect and are therefore provided pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious immune-related disorders. further combined compositions kits combining (II) with an additional therapeutic agent.

参考文章(20)
Erhard Bieberich, Raphael M. Ottenbrite, Robert K. Yu, Helen Fillmore, William C. Broaddus, Hydroxyalkyl amide analogs of ceramide ,(2000)
Jacek Slon-Usakiewicz, Screening methods for amyloid beta modulators ,(2007)
Isao Yamatsu, Kouji Nakamoto, Shinichi Kitamura, Koukichi Harada, Tohru Fujimori, Akiharu Kajiwara, Takeshi Suzuki, Shinya Abe, Polyprenyl compound, process for the production thereof and drug containing the same ,(1986)
Alberta Leon, Gabriele Marcolongo, Silvana Lorenzi, Francesco Della Valle, Therapeutic use of mono and bicarboxylic acid amides active at the peripheral cannabinoid receptor ,(1995)
Irena Krodkiewska, Gregory Goodman Warr, Calum John Drummond, Patrick Gordon Hartley, Celesta Fong, Annette Joan Murphy, Russell John Tait, Yuerong Rose Ye, Darrell Wells, Benjamin James Boyd, Darryl Vanstone Whittaker, Gregory Andrew Davey, Urea-, glycerate- and, hydroxyamide-headed hydrocarbon chain lyotropic phases forming surfactants ,(2003)
Lawrence P. Klemann, Ronald G. Yarger, John W. Finley, Amide ether derivatives as low calorie fat mimetics ,(1990)
Shigeo Sasaki, Masahiko Yoneta, Tetsuro Fujita, Tadashi Yoshitomi Pharmac. Ind. Ltd. Mishina, Kunitomo Yoshitomi Pharmac. Ind. Ltd. Adachi, Kenji Yoshitomi Pharmac. Ind. Ltd Chiba, 2-amino-1,3-propanediol compound and immunosuppressant ,(1993)