Diminished thymosinalpha‐1levels in persons exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin
作者： Paul A. Stehr‐Green , Paul H. Naylor , Richard E. Hoffman
DOI: 10.1080/15287398909531349
关键词: Immunity 、 Environmental exposure 、 Endocrinology 、 Hormone 、 Toxicity 、 Animal studies 、 Biology 、 Immune system 、 Lymphatic system 、 Internal medicine 、 Thymosin 、 Toxicology 、 Pollution
摘要: There is evidence from animal studies that 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) impairs immune responses, with the thymus being a principal target organ. The purpose of this study was to evaluate thymic function, through measurement hormone levels, in persons exposed TCDD. We examined thymosin alpha‐1 (Thy a‐1 ) levels sera group 94 who were presumed be TCDD living, working, or recreating contaminated residential area. compared these results, along results vitro and vivo tests those 105 unexposed similar regard age, sex, race. had significantly lower mean Thy serum level (977.3 ± 304.1 pg/ml vs. 1148.7 482.1 pg/ml, p < .01 by t‐test). also found statistically significant trend decreasing increasing number years residence TCDD‐contaminated However, not associated w...
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