Atropine and ODQ antagonize tetanic fade induced by L-arginine in cats.
作者： JM Cruciol-Souza , W Alves-Do-Prado , None
DOI: 10.1590/S0100-879X1999001000015
关键词: Pharmacology 、 Anesthesia 、 Snap 、 Inhibitory postsynaptic potential 、 Atropine 、 Muscarinic acetylcholine receptor 、 Nitric oxide 、 Fade 、 Cholinergic 、 Acetylcholine 、 Chemistry
摘要: Although it has been demonstrated that nitric oxide (NO) released from sodium nitrite induces tetanic fade in the cat neuromuscular preparations, effect of L-arginine on and its origin induced by NO have not studied these preparations. Furthermore, atropine reduces several cholinergic anticholinergic drugs whose mechanism is suggested to be mediated interaction acetylcholine with inhibitory presynaptic muscarinic receptors. The present study was conducted cats determine effects alone or after pretreatment 1H-[1,2, 4]oxadiazole [4,3-a]quinoxalin-1-one (ODQ) preparations indirectly stimulated at high frequency. Drugs were injected into middle genicular artery. (2 mg/kg) S-nitroso-N-acetylpenicillamine (SNAP; 16 microg/kg) fade. Nomega-nitro-L-arginine (L-NOARG; 2 did produce any effect, but reduced L-arginine. D-arginine induce changes SNAP previous injection (1.0 ODQ (15 microg/kg). change data suggest NO-synthase-GC pathway participates L-arginine-induced probably depends action level. may stimulate guanylate cyclase increasing release thereby stimulating
sci-hub.se 参考文章(21)
H. Kilbinger, Modulation of acetylcholine release by nitric oxide. Progress in Brain Research. ,vol. 109, pp. 219- 224 ,(1996) , 10.1016/S0079-6123(08)62105-6
Joan Ribera, Nitric oxide synthase in rat neuromuscular junctions and in nerve terminals of Torpedo electric organ: its role as regulator of acetylcholine release. Journal of Neuroscience Research. ,vol. 51, pp. 90- 102 ,(1998) , 10.1002/(SICI)1097-4547(19980101)51:1<90::AID-JNR10>3.0.CO;2-C
Salvador Moncada, Richard M.J. Palmer, E.Annie Higgs, Biosynthesis of nitric oxide from l-arginine: A pathway for the regulation of cell function and communication Biochemical Pharmacology. ,vol. 38, pp. 1709- 1715 ,(1989) , 10.1016/0006-2952(89)90403-6
R M Palmer, S Moncada, E A Higgs, NITRIC OXIDE: PHYSIOLOGY, PATHOPHYSIOLOGY, AND PHARMACOLOGY Pharmacological Reviews. ,vol. 43, pp. 109- 142 ,(1991)
Anibal Galindo, The role of prejunctional effects in myoneural transmission. Anesthesiology. ,vol. 36, pp. 598- 608 ,(1972) , 10.1097/00000542-197206000-00014
Célia Regina Ambiel, Wilson Alves-Do-Prado, Neuromuscular facilitation and blockade induced by L-arginine and nitric oxide in the rat isolated diaphragm. General Pharmacology-the Vascular System. ,vol. 28, pp. 789- 794 ,(1997) , 10.1016/S0306-3623(96)00237-6
C.L. Boulton, E. Southam, J. Garthwaite, Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase Neuroscience. ,vol. 69, pp. 699- 703 ,(1995) , 10.1016/0306-4522(95)00349-N
Alan Gibson, Elliot Lilley, Superoxide anions, free-radical scavengers, and nitrergic neurotransmission General Pharmacology-the Vascular System. ,vol. 28, pp. 489- 493 ,(1997) , 10.1016/S0306-3623(96)00281-9
C.K. Chow, C.B. Hong, M.E. Reese, C. Gairola, Effect of dietary vitamin E on nitrite-treated rats Toxicology Letters. ,vol. 23, pp. 109- 117 ,(1984) , 10.1016/0378-4274(84)90016-X
D. M. Michaelson, S. Avissar, Y. Kloog, M. Sokolovsky, Mechanism of acetylcholine release: possible involvement of presynaptic muscarinic receptors in regulation of acetylcholine release and protein phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 6336- 6340 ,(1979) , 10.1073/PNAS.76.12.6336