Neuromuscular facilitation and blockade induced by L-arginine and nitric oxide in the rat isolated diaphragm.
作者： Célia Regina Ambiel , Wilson Alves-Do-Prado
DOI: 10.1016/S0306-3623(96)00237-6
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摘要: Abstract 1. L-Arginine (4.7–9.5 mM) induced an increase in the amplitude of muscular contraction (AMC) evoked by nerve stimulation rat diaphragm preparations, but produced a reduction AMC direct muscles previously treated with d-tubocurarine. The facilitatory dose L-arginine was ineffective changing twitch tension retrograde injection acetylcholine. 2. N ω -nitro-L-arginine (18 antagonized preparations indirectly stimulated, and similar effect obtained against depression directly stimulated muscle preparations. D-Arginine (4.5–9.5 or indirect diaphragm. 3. NO (8.6 followed muscles, smaller than neuromuscular effect. 4. These results indicate that increases when it interacts at presynaptic level decreases postsynaptic level.
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