Differential Gene Expression in Ovarian Carcinoma : Identification of Potential Biomarkers
作者： Kathleen Hibbs , Keith M. Skubitz , Stefan E. Pambuccian , Rachael C. Casey , Kathryn M. Burleson
DOI: 10.1016/S0002-9440(10)63306-8
关键词: Gene expression 、 Retinoic acid binding 、 Gene 、 Pathology 、 Ovary 、 Ovarian cancer 、 Biology 、 Immunohistochemistry 、 Gene expression profiling 、 Ovarian carcinoma
摘要: Ovarian cancer remains the fifth leading cause of death for women in United States. In this study, gene expression 20 ovarian carcinomas, 17 carcinomas metastatic to omentum, and 50 normal ovaries was determined by Gene Logic Inc. using Affymetrix GeneChip HU_95 arrays containing ∼12,000 known genes. Differences were quantified as fold changes compared carcinoma metastases. Genes up-regulated tissue samples more than 300 other diseased identified. Seven genes selected further screening immunohistochemistry determine presence localization proteins. These seven were: β8 integrin subunit, bone morphogenetic protein-7, claudin-4, collagen type IX α2, cellular retinoic acid binding protein-1, forkhead box J1, S100 calcium-binding protein A1. Statistical analyses showed that S100A1 provided best distinction between ovary tissues, may serve candidate tumor markers among studied. results suggest exploration into identify novel diagnostic, therapeutic, and/or prognostic biomarkers carcinoma.
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