New determinates of disease progression and outcome in metastatic ovarian carcinoma.

摘要: Ovarian cancer is the most lethal gynecologic malignancy. This attributed to frequent presentation at late stage, when tumor has metastasized, as well development of chemotherapy resistance along progression. Patients with advanced-stage ovarian carcinoma have widespread intraperitoneal metastases, including formation malignant serous effusions within peritoneal cavity. Pleural constitute site distant metastasis (FIGO stage IV disease). Unlike majority solid tumors, particularly primary site, cells in are not amenable surgical removal, and failure their eradication one main causes treatment failure. Our research recent years demonstrated that a large number cancer-associated molecules differentially expressed compared carcinomas metastases. We additionally observed expression several these differs between diagnosis (pre-chemotherapy) disease recurrence (post-chemotherapy) specimens, they significantly associated response patient survival. These observations thought be related progression, unique microenvironment effusions, may impact on selection targeted therapy this cancer. review discusses our respect biology focuses clinical role tumor-associated anatomic site.