Preparing 2-fluoroadenine, comprises converting 2,6-diaminopurine in the presence of nitrite, heating the mixture, mixing and quenching the heated mixture, separating, preferably filtering the mixture, washing the solid materials

摘要: Preparation of 2-fluoroadenine, comprises: converting 2,6-diaminopurine in a water-free fluorinating agent the presence nitrite; heating reaction mixture after adding mixing and quenching heated under stirring water; separating, preferably filtering obtained mixture; washing solid materials with material without additional cleaning steps drying to obtain 2-fluoroadenine (53-68, 54-60%) purity at least 98%. nitrite -30 -10[deg] C, -20 -12[deg] C; for period 0.5-4 hours, 1-1.5 hours -5 5, 0[deg] 7-13 folds, 8 folds water quantity kilogram, relative used kilogram; 4-7, 5 7-13, quantity, which is kilograms, fixed agents kilograms; subsequent 70-85, 80[deg] C vacuum