Process for producing 2,6-dihalogenopurine
作者： Junichi Nishikawa , Naruhito Masai , Istvan Barta , Takehiko Kawakami , Taketo Hayashi
DOI:
关键词:
摘要: A process for easily and efficiently producing a 2,6-dihalogenopurine from an inexpensive starting material. The is characterized by causing diazotizing agent halogen source to act on 2-amino-6-halogenopurine having protective group in the 7- or 9-position. Also provided 9-acyl-2-amino-6-halogenopurine, acylating presence of base.
lens.org 参考文章(19)
Hiroharu Sumika Fine Chem. Co. Ltd. Kumazawa, Taketo Sumika Fine Chem. Co. Ltd. Hayashi, Junichi Sumika Fine Chem. Co. Ltd. Nishikawa, Process for preparing 2,6-dichloropurine ,(2001)
Gemma Caroline Stratton, Joanne Lerpiniere, Scott Murray Weiss, Claire Elizabeth Dawson, Robert Mark Pratt, Suneel Gaur, Roger John Gillespie, Purine derivatives as purinergic receptor antagonists ,(2002)
John Christopher Hanson, Preparation of penciclovir or famciclovir ,(1999)
Elizabeth Dyer, Carl E. Minnier, Acylations of some 2-amino-6-halo-and 2-amino-6-alkylthiopurines. Journal of Medicinal Chemistry. ,vol. 11, pp. 1232- 1234 ,(1968) , 10.1021/JM00312A032
Anupma Dhanda, Lars J. S. Knutsen, May-Britt Nielsen, Stanley M. Roberts, David R. Varley, Facile conversion of 4-endo-hydroxy-2-oxabicyclo[3.3.0]oct-7-en-3-one into carbocyclic 2′-deoxyribonucleoside analogues Journal of The Chemical Society-perkin Transactions 1. pp. 3469- 3475 ,(1999) , 10.1039/A906464H
Seung B. Ha, Neli Melman, Kenneth A. Jacobson, Vasu Nair, NEW BASE-ALTERED ADENOSINE ANALOGUES: SYNTHESIS AND AFFINITY AT ADENOSINE A1 and A2A RECEPTORS. Bioorganic & Medicinal Chemistry Letters. ,vol. 7, pp. 3085- 3090 ,(1997) , 10.1016/S0960-894X(97)10177-9
Suzanne E. Keeling, F.David Albinson, Barry E. Ayres, Peter R. Butchers, C.Lynn Chambers, Peter C. Cherry, Frank Ellis, George B. Ewan, Michael Gregson, John Knight, Keith Mills, Paul Ravenscroft, Linda H. Reynolds, Shahin Sanjar, Michael J. Sheehan, The discovery and synthesis of highly potent, A2a receptor agonists. Bioorganic & Medicinal Chemistry Letters. ,vol. 10, pp. 403- 406 ,(2000) , 10.1016/S0960-894X(00)00017-2
Paula Francom, Zlatko Janeba, Susumu Shibuya, Morris J. Robins, Nucleic acid related compounds. 116. Nonaqueous diazotization of aminopurine nucleosides. Mechanistic considerations and efficient procedures with tert-butyl nitrite or sodium nitrite. Journal of Organic Chemistry. ,vol. 67, pp. 6788- 6796 ,(2002) , 10.1021/JO0204101
Nathanael S. Gray, Soojin Kwon, Peter G. Schultz, Combinatorial synthesis of 2,9-substituted purines Tetrahedron Letters. ,vol. 38, pp. 1161- 1164 ,(1997) , 10.1016/S0040-4039(97)00014-2
V. NAIR, S. G. RICHARDSON, Modification of Nucleic Acid Bases via Radical Intermediates: Synthesis of Dihalogenated Purine Nucleosides Synthesis. ,vol. 1982, pp. 670- 672 ,(1982) , 10.1002/CHIN.198301355