Hypoxic fraction and repair of potentially lethal radiation damage in two human melanomas transplanted into nude mice.
作者： Nicole Chavaudra , Marcelle Guichard , Edmond-Philippe Malaise
DOI: 10.2307/3575751
关键词: Tumor excision 、 In vitro 、 Biology 、 Cancer research 、 Radiosensitivity 、 Human melanoma 、 Radiation therapy 、 Hypoxic cell 、 Radiation damage 、 Pathology 、 Radioresistance
摘要: The radiosensitivity of two human cell lines, Ma 11 and Be 11, each arising from a melanoma, was studied. tumors were transplanted into nude mice irradiated in situ, the colony-forming ability tested vitro. D/sub 0/ values obtained under these conditions 4.22 5.85 Gy for respectively. surviving fraction cells increased when tumor excision delayed 6 hr. line contained 40% hypoxic cells; corresponding figure 62%. These figures like that previously determined another malanoma (85%), are among highest reported literature. For solid tumors, only 10% have greater than 40%; this high may partially explain radioresistance melanomas.
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sci-hub.se 参考文章(31)
R. Quick, B. Keller, M. Friedman, P. Rubin, Range of prescribed tumor lethal doses (PTLD) in the treatment of different human tumors Charles C Thomas, Springfield, IL. ,(1974)
R. M. Humphrey, S. C. Barranco, M. M. Romsdahl, The Radiation Response of Human Malignant Melanoma Cells Grown in Vitro Cancer Research. ,vol. 31, pp. 830- 833 ,(1971)
J Mills, M J Peckham, V D Courtenay, I E Smith, In vitro radiation response of cells from four human tumors propagated in immune-suppressed mice. Cancer Research. ,vol. 38, pp. 390- 392 ,(1978)
Dennis F. Deen, Michael Weizsaecker, Effect of feeder cell-released substances on the survival of clonogenic 9L cells after treatment with antimetabolites. Cancer Research. ,vol. 40, pp. 3202- 3205 ,(1980)
G. W. Barendsen, H. Roelse, A. F. Hermans, H. T. Madhuizen, H. A. van Peperzeel, D. H. Rutgers, Clonogenic Capacity of Proliferating and Nonproliferating Cells of a Transplantable Rat Rhabdomyosarcoma in Relation to its Radiosensitivity JNCI: Journal of the National Cancer Institute. ,vol. 51, pp. 1521- 1526 ,(1973) , 10.1093/JNCI/51.5.1521
K.B. Dawson, H. Madoc-Jones, F. Mauro, J.H. Peacock, Studies on the radiobiology of a rat sarcoma treated in situ and assayed in vitro European Journal of Cancer (1965). ,vol. 9, pp. 59- 68 ,(1973) , 10.1016/0014-2964(73)90044-3
Marcelle Guichard, Frédérique de Langen-Omri, Edmond-Philippe Malaise, Influence of misonidazole on the radiosensitivity of a human melanoma in nude mice: Time-dependent increase in surviving fraction International Journal of Radiation Oncology*Biology*Physics. ,vol. 5, pp. 487- 489 ,(1979) , 10.1016/0360-3016(79)90811-3
Bernard Fertil, Edmond-Philippe Malaise, Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy International Journal of Radiation Oncology Biology Physics. ,vol. 7, pp. 621- 629 ,(1981) , 10.1016/0360-3016(81)90377-1
Robert F. Kallman, The phenomenon of reoxygenation and its implications for fractionated radiotherapy. Radiology. ,vol. 105, pp. 135- 142 ,(1972) , 10.1148/105.1.135
Janet S. Rasey, Norma J. Nelson, Effect of tumor dissaggregation on results of in vitro cell survival assay after in vivo treatment of the EMT-6 tumor: x-rays, cyclophosphamide, and bleomycin. In Vitro Cellular & Developmental Biology – Plant. ,vol. 16, pp. 547- 553 ,(1980) , 10.1007/BF02618377