Characterization of highly pathogenic avian influenza H5N8 virus from Egyptian domestic waterfowl in 2017.
作者： Mohammed AboElkhair , Mahmoud Ibrahim , Anis Anis
DOI: 10.1080/03079457.2018.1470606
关键词: Clade 、 Virus 、 Hydropic degeneration 、 Influenza A virus subtype H5N1 、 Biology 、 Transmission (medicine) 、 Virology 、 Encephalitis 、 Waterfowl 、 Reassortant Viruses
摘要: In 2016, the highly pathogenic avian influenza (HPAI) H5N8 virus was detected in wild birds for first time Egypt. present study, we identified HPAI of clade 2.3.4.4 from domestic waterfowl Egypt, suggesting its transmission to poultry migratory birds. Based on partial haemagglutinin gene sequence, this has a close genetic relationship with subtype viruses circulating Asia and Europe. Pathologically, hybrid duck induced nervous signs accompanied by encephalomalacia, haemorrhages, nonsuppurative encephalitis vasculitis. The granular layer cerebellum showed multifocal areas hydropic degeneration Purkinje cell neurons were necrotized or lost. Additionally, lung, kidney spleen congested, necrotizing pancreatitis also observed. co-circulation both H5N1 subtypes low H9N2 complicate control Egypt possibility emergence new reassortant viruses. Therefore, continuous monitoring implementation strict measures is required. Research highlights ducks geese 2017. Phylogenetically, closely related Europe Nonsuppurative widely observed virus-infected ducks. Degeneration cerebellar found most brain tissues examined.
sci-hub.se 参考文章(36)
Isabella Monne, Hussein A. Hussein, Alice Fusaro, Viviana Valastro, Mohamed M. Hamoud, Rabab A. Khalefa, Shahin N. Dardir, Moustafa I. Radwan, Ilaria Capua, Giovanni Cattoli, H9N2 influenza A virus circulates in H5N1 endemically infected poultry population in Egypt Influenza and Other Respiratory Viruses. ,vol. 7, pp. 240- 243 ,(2013) , 10.1111/J.1750-2659.2012.00399.X
A. Núñez, S. M. Brookes, S. M. Reid, C. Garcia-Rueda, D. J. Hicks, J. M. Seekings, Y. I. Spencer, I. H. Brown, Highly Pathogenic Avian Influenza H5N8 Clade 2.3.4.4 Virus: Equivocal Pathogenicity and Implications for Surveillance Following Natural Infection in Breeder Ducks in the United Kingdom. Transboundary and Emerging Diseases. ,vol. 63, pp. 5- 9 ,(2016) , 10.1111/TBED.12442
Juan Li, Min Gu, Dong Liu, Benqi Liu, Kaijun Jiang, Lei Zhong, Kaituo Liu, Wenqi Sun, Jiao Hu, Xiaoquan Wang, Shunlin Hu, Xiaowen Liu, Xiufan Liu, Phylogenetic and biological characterization of three K1203 (H5N8)-like avian influenza A virus reassortants in China in 2014. Archives of Virology. ,vol. 161, pp. 289- 302 ,(2016) , 10.1007/S00705-015-2661-2
Magdi D. Saad, Lu’ay S. Ahmed, Mohamed A. Gamal-Eldein, Mohamed K. Fouda, Fouda M. Khalil, Samuel L. Yingst, Michael A. Parker, Marshall R. Montevillel, Possible Avian Influenza (H5N1) from Migratory Bird, Egypt Emerging Infectious Diseases. ,vol. 13, pp. 1120- 1121 ,(2007) , 10.3201/EID1307.061222
Dong-Hun Lee, Mia Kim Torchetti, Kevin Winker, Hon S. Ip, Chang-Seon Song, David E. Swayne, Intercontinental Spread of Asian-origin H5N8 to North America through Beringia by Migratory Birds Journal of Virology. ,vol. 89, pp. 6521- 6524 ,(2015) , 10.1128/JVI.00728-15
Hon S. Ip, Mia Kim Torchetti, Rocio Crespo, Paul Kohrs, Paul DeBruyn, Kristin G. Mansfield, Timothy Baszler, Lyndon Badcoe, Barbara Bodenstein, Valerie Shearn-Bochsler, Mary Lea Killian, Janice C. Pedersen, Nichole Hines, Thomas Gidlewski, Thomas DeLiberto, Jonathan M. Sleeman, Novel Eurasian highly pathogenic avian influenza A H5 viruses in wild birds, Washington, USA, 2014. Emerging Infectious Diseases. ,vol. 21, pp. 886- 890 ,(2015) , 10.3201/EID2105.142020
E.M. Abdelwhab, Christian Grund, Mona M. Aly, Martin Beer, Timm C. Harder, Hafez M. Hafez, Multiple dose vaccination with heterologous H5N2 vaccine: immune response and protection against variant clade 2.2.1 highly pathogenic avian influenza H5N1 in broiler breeder chickens. Vaccine. ,vol. 29, pp. 6219- 6225 ,(2011) , 10.1016/J.VACCINE.2011.06.090
Mahmoud Ibrahim, Abdelfattah H. Eladl, Hesham A. Sultan, Abdel Satar Arafa, Alaa G. Abdel Razik, Sahar Abd El Rahman, Kamel I. Abou El-Azm, Yehia M. Saif, Chang-Won Lee, Antigenic analysis of H5N1 highly pathogenic avian influenza viruses circulating in Egypt (2006-2012). Veterinary Microbiology. ,vol. 167, pp. 651- 661 ,(2013) , 10.1016/J.VETMIC.2013.09.022
Haibo Wu, Xiaorong Peng, Lihua Xu, Changzhong Jin, Linfang Cheng, Xiangyun Lu, Tiansheng Xie, Hangping Yao, Nanping Wu, Novel Reassortant Influenza A(H5N8) Viruses in Domestic Ducks, Eastern China Emerging Infectious Diseases. ,vol. 20, pp. 1315- 1318 ,(2014) , 10.3201/EID2008.140339
Hye-Ryoung Kim, Yong-Kuk Kwon, Il Jang, Youn-Jeong Lee, Hyun-Mi Kang, Eun-Kyoung Lee, Byung-Min Song, Hee-Soo Lee, Yi-Seok Joo, Kyung-Hyun Lee, Hyun-Kyoung Lee, Kang-Hyun Baek, You-Chan Bae, Pathologic Changes in Wild Birds Infected with Highly Pathogenic Avian Influenza A(H5N8) Viruses, South Korea, 2014. Emerging Infectious Diseases. ,vol. 21, pp. 775- 780 ,(2015) , 10.3201/EID2105.141967