Histone H3 phosphorylation and cell division

作者: Fabienne Hans , Stefan Dimitrov

DOI: 10.1038/SJ.ONC.1204326

关键词: Histone H2ACell biologyHistone H3MetaphaseHistone H1BiologyCell divisionPhosphorylationMitosisChromatinGeneticsCancer researchMolecular biology

摘要: Histone H3 is specifically phosphorylated during both mitosis and meiosis in patterns that are coordinated space time. phosphorylation may initiate at different phases of the cell division organisms, but metaphase chromosomes always found to be heavily phosphorylated. Upon exit mitosis/meiosis a global dephosphorylation takes place. Potential candidates for kinases described their hypothetical mechanism action on highly condensed chromatin templates discussed. In addition, novel hypothesis role histone proposed. This hypothesis, termed 'ready production label' model, explains results literature suggests part complex signaling mechanism.

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