Intravenous opioid testing in patients with chronic non‐cancer pain
DOI: 10.1016/J.EJPAIN.2004.05.006
关键词: Opioid 、 Placebo 、 In patient 、 Anesthesia 、 Non cancer 、 Maximum dose 、 Remifentanil 、 Ambulatory 、 Medicine
摘要: Abstract The clinical use of an intravenous opioid testing can help to predict whether opioids will be beneficial. determination individual responsiveness justifies subsequent long-term treatment and is generally recommended. An overview over current procedures given with particular regard choice opioid, maximum dose, endpoints duration recovery. Remifentanil a new approch studied in randomized placebo-controlled cross-over study 24 patients suffering from severe non-cancer pain. ascending infusion remifentanil placebo respectively was titrated against endpoints. allowed disctinction between 11 opioid-responders 13 non-responders. Complete recovery after end rapid reach baseline conditions 25 min all patients. Thus the complete procedure required at utmost 1 h. In conclusion, offers more allowing routine ambulatory setting.
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