Hub discovery in partial correlation graphical models

作者: Bala Rajaratnam , Alfred Hero

DOI:

关键词: Block (data storage)Partial correlationNetwork securityNode (networking)Graphical modelGraph (abstract data type)Theoretical computer scienceDegree (graph theory)Data miningMathematicsExpression (mathematics)

摘要: This paper treats the problem of screening a p-variate sample for strongly and multiply connected vertices in partial correlation graph associated with matrix sample. problem, called hub screening, is important many applications ranging from network security to computational biology finance social networks. In area security, node that becomes high neighboring nodes might signal anomalous activity such as coordinated flooding attack. set hubs gene expression can serve potential targets drug treatment block pathway or modulate host response. indicate vulnerable financial instrument sector whose collapse have major repercussions on market. networks observed interactions between criminal suspects could be an influential ringleader. The techniques theory presented this permit scalable reliable hubs. extends our previous work [arXiv:1102.1204] more challenging variables degree connectivity. particular we consider 1) extension difficult correlations exceeding specified magnitude; 2) vertex graph, often concentration exceeds degree.

参考文章(17)
Richard Arratia, Larry Goldstein, Louis Gordon, Poisson Approximation and the Chen-Stein Method Statistical Science. ,vol. 5, pp. 403- 424 ,(1990) , 10.1214/SS/1177012015
Adam J. Rothman, Elizaveta Levina, Peter J. Bickel, Ji Zhu, Sparse permutation invariant covariance estimation Electronic Journal of Statistics. ,vol. 2, pp. 494- 515 ,(2008) , 10.1214/08-EJS176
Alfred Hero, Bala Rajaratnam, Large-Scale Correlation Screening Journal of the American Statistical Association. ,vol. 106, pp. 1540- 1552 ,(2011) , 10.1198/JASA.2011.TM11015
Juliane Schäfer, Korbinian Strimmer, A Shrinkage Approach to Large-Scale Covariance Matrix Estimation and Implications for Functional Genomics Statistical Applications in Genetics and Molecular Biology. ,vol. 4, pp. 1- 32 ,(2005) , 10.2202/1544-6115.1175
Jie Peng, Pei Wang, Nengfeng Zhou, Ji Zhu, Partial Correlation Estimation by Joint Sparse Regression Models. Journal of the American Statistical Association. ,vol. 104, pp. 735- 746 ,(2009) , 10.1198/JASA.2009.0126
Ryan Gill, Somnath Datta, Susmita Datta, A statistical framework for differential network analysis from microarray data BMC Bioinformatics. ,vol. 11, pp. 95- 95 ,(2010) , 10.1186/1471-2105-11-95
Elizaveta Levina, Peter J. Bickel, Covariance regularization by thresholding arXiv: Statistics Theory. ,(2009) , 10.1214/08-AOS600
V. Pihur, S. Datta, S. Datta, Reconstruction of genetic association networks from microarray data Bioinformatics. ,vol. 24, pp. 561- 568 ,(2008) , 10.1093/BIOINFORMATICS/BTM640
A. Wiesel, Y.C. Eldar, A.O. Hero, Covariance Estimation in Decomposable Gaussian Graphical Models IEEE Transactions on Signal Processing. ,vol. 58, pp. 1482- 1492 ,(2010) , 10.1109/TSP.2009.2037350