Regulatory T cells: how do they find their space in the immunological arena?

摘要: After more of a decade controversy, the concept suppressor T cells initially promoted by Gershon, has now become an established paradigm. Current knowledge withholds that populations or regulatory (Treg cells) constitute pivotal mechanism immunological tolerance. Diverse types Treg cells, with distinct origins, disparate and multiple functions have been described. However, despite recognized importance in regulating immune responses, our understanding their significance, action interplay other means tolerance is still its infancy. Increased comprehension how exert function holds promise for therapeutic intervention manipulating one most sophisticated features immunity to either boost responses cancer microbial diseases suppresses those unwanted autoimmunity transplantation. Here, I will discuss new findings open questions related CD25(+)Treg attempt cover some puzzling aspects functioning these cells.