Porous hydroxyapatite scaffolds containing dual microspheres based on poly(lactide-co-glycolide) and chitosan for bone regeneration
作者： Qin Wang , Jinyu Li , Taotao Xu , Xiaoying Lu , Wei Zhi
DOI: 10.1016/J.MATLET.2016.11.098
关键词: Chitosan 、 Composite material 、 Drug delivery 、 Materials science 、 Scaffold 、 Coating 、 Chemical engineering 、 Bone regeneration 、 Emulsion 、 PLGA 、 Bone tissue 、 Mechanical engineering 、 General Materials Science 、 Mechanics of Materials 、 Condensed matter physics
摘要: Abstract The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field bone engineering. aim this study was incorporate dual microspheres with different diameters, based on chitosan (CS) poly(lactide-co-glycolide) (PLGA), onto porous surface hydroxyapatite scaffolds (HAs). were prepared by sphere-leaching method emulsion technique, respectively. Through electrostatic interactions, CS PLGA successfully immobilized alginate-precoated HAs. homogeneously solidly HAs, whereas attached microspheres. Additionally, compressive strength obviously improved alginate coating. Such HAs combined two types build a system would be promising suitable vehicle for repair defects.
elsevier.com
sci-hub.se 参考文章(15)
Peng Zhai, X.B. Chen, David J. Schreyer, PLGA/alginate composite microspheres for hydrophilic protein delivery. Materials Science and Engineering: C. ,vol. 56, pp. 251- 259 ,(2015) , 10.1016/J.MSEC.2015.06.015
Manuela E. Gomes, Heidi L. Holtorf, Rui L. Reis, Antonios G. Mikos, Influence of the porosity of starch-based fiber mesh scaffolds on the proliferation and osteogenic differentiation of bone marrow stromal cells cultured in a flow perfusion bioreactor. Tissue Engineering. ,vol. 12, pp. 801- 809 ,(2006) , 10.1089/TEN.2006.12.801
Lydia Francis, Decheng Meng, Jonathan C. Knowles, Ipsita Roy, Aldo R. Boccaccini, Multi-functional P(3HB) microsphere/45S5 Bioglass-based composite scaffolds for bone tissue engineering. Acta Biomaterialia. ,vol. 6, pp. 2773- 2786 ,(2010) , 10.1016/J.ACTBIO.2009.12.054
Wei Li, Yaping Ding, Ranjana Rai, Judith A. Roether, Dirk W. Schubert, Aldo R. Boccaccini, Preparation and characterization of PHBV microsphere/45S5 bioactive glass composite scaffolds with vancomycin releasing function Materials Science and Engineering: C. ,vol. 41, pp. 320- 328 ,(2014) , 10.1016/J.MSEC.2014.04.052
Jun Sik Son, Mark Appleford, Joo L. Ong, Joseph C. Wenke, Jong Min Kim, Seok Hwa Choi, Daniel S. Oh, Porous hydroxyapatite scaffold with three-dimensional localized drug delivery system using biodegradable microspheres. Journal of Controlled Release. ,vol. 153, pp. 133- 140 ,(2011) , 10.1016/J.JCONREL.2011.03.010
Marguerite Rinaudo, Main properties and current applications of some polysaccharides as biomaterials Polymer International. ,vol. 57, pp. 397- 430 ,(2008) , 10.1002/PI.2378
Darmawati Mohamad Yunos, Oana Bretcanu, Aldo R. Boccaccini, Polymer-bioceramic composites for tissue engineering scaffolds Journal of Materials Science. ,vol. 43, pp. 4433- 4442 ,(2008) , 10.1007/S10853-008-2552-Y
M. Lebourg, R. Sabater Serra, J. Más Estellés, F. Hernández Sánchez, J. L. Gómez Ribelles, J. Suay Antón, Biodegradable polycaprolactone scaffold with controlled porosity obtained by modified particle-leaching technique Journal of Materials Science: Materials in Medicine. ,vol. 19, pp. 2047- 2053 ,(2008) , 10.1007/S10856-007-3282-4
X. Yang, L. Zhang, X. Chen, G. Yang, L. Zhang, C. Gao, H. Yang, Z. Gou, Trace element-incorporating octacalcium phosphate porous beads via polypeptide-assisted nanocrystal self-assembly for potential applications in osteogenesis. Acta Biomaterialia. ,vol. 8, pp. 1586- 1596 ,(2012) , 10.1016/J.ACTBIO.2011.12.012
B SARMENTO, D FERREIRA, F VEIGA, A RIBEIRO, Characterization of insulin-loaded alginate nanoparticles produced by ionotropic pre-gelation through DSC and FTIR studies Carbohydrate Polymers. ,vol. 66, pp. 1- 7 ,(2006) , 10.1016/J.CARBPOL.2006.02.008