CORRELATIONS BETWEEN LIQUID CHROMATOGRAPHIC CAPACITY RATIO DATA ON LICHROSORB RP-18 AND PARTITION COEFFICIENTS IN THE OCTANOL-WATER SYSTEM

摘要: SUMMARY Retention data of methylbenzenes, n-alkylbenzenes, fused arenes, polyphenyls, chlorobenzenes, -anilines and -phenols some polar monosubstituted benzenes have been measured on LiChrosorb RP-18, using methanol-water mixtures as eluents at 25’C. The important effect solute activity coefficients in water capacity ratio (k) data, holding for eluent, partition the octanol-water system (PO,,_) is shown. log k-log I’,,,,_ correlation improved by (1inearIy extrapolated) X- values water, instead those mixtures. At similar Pact_ k are slightly higher than lipophilic compounds_ Consequently, two Pa,,_ regression equations proposed. Steric intramolecular electronic effects P,,,,_ halogenated anilines phenols described quantitatively. results cast doubt reliability Rekker’sf-method prediction PO,,_ highly substituted aromatic