White coat hypertension in NIDDM patients with and without incipient and overt diabetic nephropathy

摘要: OBJECTIVE Early data have suggested a high prevalence of white coat hypertension (∼ 50%) in NIDDM patients. To study this phenomenon further, we determined the patients with normo- or microalbuminuria diabetic nephropathy. RESEARCH DESIGN AND METHODS Three groups hypertensive (repeated clinic blood pressure > 140/90 mmHg antihypertensive treatment) attending Steno Diabetes Center were investigated cross-sectional study. Group 1 had normoalbuminuria (a urinary albumin excretion [UAE] rate 300 mg/24h, n = 47, 62 ± 7 years, 36 men). If given, all previous medication was withdrawn at least 2 weeks before (48%). The (clinic normal values home) by comparison (Hawksley Random sphygmomanometer) and ambulatory daytime (7:00 A.M. to 11:00 P.M.) (A&D TM2420). By applying established criteria, confirmed if RESULTS 155/86 (SE 3/2) mmHg, 156/89 (2/1) 171/90 (3/2) group 1, 2, 3, respectively (P CONCLUSIONS normoalbuminuric resembles that observed nondiabetic subjects essential hypertension, whereas is significantly lower incipient overt nephropathy, suggesting difference between primary secondary hypertension.