Oxidized phosphatidylcholines in membrane-level cellular signaling: from biophysics to physiology and molecular pathology.

摘要: The oxidation of lipids has been shown to impact virtually all cellular processes. paradigm that this involvement is due interference with the functions membrane-associated proteins. It only recently methodological advances in molecular-level detection and identification have begun provide insights into oxidative lipid modification its cell signaling as well major diseases inflammation. Extensive evidence suggests a correlation between peroxidation degenerative neurological such Parkinson's Alzheimer's, type 2 diabetes cancer. Despite obvious relevance understanding molecular basis above ailments, exact modes action oxidized remained elusive. In minireview, we summarize recent findings on biophysical characteristics biomembranes following derivatization their lipids, how these altered properties are involved both physiological processes pathological conditions. Lipid-bearing, oxidatively truncated functionalized acyl chains known modify membrane bulk physical properties, thermal phase behavior, bilayer thickness, hydration polarity profiles, manifest structural dynamics bilayers, leading augmented permeability, fast transbilayer diffusion (flip-flop), loss asymmetry (scrambling) segregation (the formation 'rafts'). These changes, together generated reactive derivatives, can be further expected interfere lipid-protein interactions, influencing metabolic pathways, causing inflammation, execution apoptosis initiating