Somatic cell mutations in cancer epidemiology.

摘要: Somatic cell mutations arising in vivo reporter genes and cancer-associated may now be measured humans. Background mutation levels mutational responses following various mutagen exposures are reviewed this chapter. The detection methods compared for similarities differences based on the underlying biology of systems. Currently available data molecular spectra utility such information is discussed terms exposure characterization defining mutagenic basis carcinogenesis. In addition to gene assays, recently developed assays considered. strengths limitations using somatic cancer epidemiology areas future research discussed.