Potential Association Between Asthma, Helicobacter pylori Infection, and Gastric Cancer.

摘要: Background: The prevalence of Helicobacter pylori infection (HPI) is still high around the world, which induces gastric diseases, such as cancer (GC). epidemiological investigation showed that there was an association between HPI and asthma (AST). Coptidis rhizoma (CR) has been reported herbal medicine with anti-inflammatory anti-bacterial effects. Purpose: present study aimed to investigate protective mechanism on AST its adverse effects development GC. Coptis chinensis used neutralize damage in GC hopefully intensify certain pathways for AST. Method: information about obtained from public database Comparative Toxicogenomics Database (CTD). related targets were GeneCards. ingredients CR Traditional Chinese Medicine Systems Pharmacology (TCMSP). network pharmacology including gene ontology (GO) enrichment analysis, Kyoto Encyclopedia Genes Genomes (KEGG) molecular docking utilized. Protein-protein interaction constructed analyze functional link target genes. employed potential active key Result: top 10 CXCL9, CX3CL1, CCL20, CCL4, PF4, CCL27, C5AR1, PPBP, KNG1, ADORA1. GO biological process involved mainly leukocyte migration, responded bacterium. (R)-canadine quercetin selected C. chinensis, explore if they inhibited synchronously protect against SLC6A4 OPRM1. For ingredient quercetin, AKR1B1 VCAM1. Conclusion: CXCL9 VCAM1 common HPI, might be one imported Quercetin could effective suppress help prevent