Soluble adhesion molecules ICAM-1, VCAM-1, P-selectin in children withHelicobacter pyloriinfection
作者： Elzbieta Maciorkowska
关键词: Helicobacter pylori 、 Gastric mucosa 、 Antrum 、 Pathogenesis 、 Gastritis 、 Chronic gastritis 、 P-selectin 、 Biology 、 Immunology 、 Stomach 、 Gastroenterology 、 General Medicine
摘要: AIM: To assess the sICAM-1, sVCAM-1, and sP-selectin levels in children with Helicobacter pylori (H pylori) infection to evaluate their significance for morphological changes found gastric mucosa. METHODS: The study included 106 children: 59 (55.7%) chronic gastritis positive IgG against H pylori, 29 (27.3%) after previous without bacterium colonization but 18 (17%) functional disorders of gastrointestinal system normal pylori. Endoscopic histopathological evaluation mucosa was performed based on Sydney System classification. sP-selectin, sVCAM-1 sera carried out using ELISA test. RESULTS: assessment activity degrees indicated statistically significant values antrum corpus (P<0.001) examined. Serum were higher group due than differed (P<0.05). proved be highest among other adhesive molecules infected decreased eradication sICAM-1 similar all examined groups. infection. CONCLUSION: Assessment (sP-selectin, sVCAM-1) active can show participation pathogenesis mucosal inflammation. concentrations cannot reveal any differences as compared healthy children.
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