Role of Helicobacter pylori infection in pathogenesis of atherosclerosis.

摘要: Though a century old hypothesis, infection as cause for atherosclerosis is still debatable issue. Epidemiological and clinical studies had shown possible association but inhomogeneity in the study population methods along with potential confounders have yielded conflicting results. Infection triggers chronic inflammatory state which other mechanisms such dyslipidemia, hyper-homocysteinemia, hypercoagulability, impaired glucose metabolism endothelial dysfunction, contribute pathogenesis of atherosclerosis. Studies positive relations between Cytotoxic associated gene-A strains Helicobacter pylori vascular diseases coronary artery disease stroke. mediated genetic modulation new emerging theory this regard. Further large scale on focusing multiple pathogenetic may help refining our knowledge aspect.