Dasatinib suppression of medulloblastoma survival and migration is markedly enhanced by combining treatment with the aurora kinase inhibitor AT9283
作者： William Petersen , Jingbo Liu , Liangping Yuan , Hongying Zhang , Matthew Schneiderjan
DOI: 10.1016/J.CANLET.2014.07.038
关键词: Aurora Kinase A 、 Medulloblastoma 、 Viability assay 、 Dasatinib 、 In vivo 、 Cell growth 、 Aurora kinase 、 Proto-oncogene tyrosine-protein kinase Src 、 Cancer research 、 Biology
摘要: Medulloblastoma (MB) expresses Src kinase, while aurora kinase A overexpression correlates with poor survival. We thus investigated novel combination treatment dasatinib and AT9283, inhibitors of respectively, on MB growth in vitro vivo. Treatment each drug significantly reduced cell viability combined markedly potentiated this response. AT9283 induced p53 expression, autophagy, G2/M cell-cycle arrest, S phase arrest. Dasatinib caused tumor regression Activated was detected 44% analyzed. conclude that further evaluation therapy for is highly warranted.
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