Multi-kinase inhibitors, AURKs and cancer

摘要: Inhibitors that impact function of kinases are valuable both for the biological research as well therapy kinase-associated diseases, such different cancers. There quite a number inhibitors, which specific certain and several them either already approved cancer or in clinical studies various phases. However, does not mean each single kinase inhibitor is suitable targeted therapy. Some effective others might be toxic fail some other criteria use vivo. On hand, even case successful therapy, many responders eventually develop resistance to inhibitors. The limitations inhibitors can fought using compounds target multiple kinases. This tactics increase effectiveness by synergistic effect help diminish likelihood drug resistance. To date, families popular targets inhibition cancers, tyrosine kinases, cycle-dependent mitogen-activated protein phosphoinositide 3-kinases their pathway "players" aurora Aurora play an important role control mitosis often altered diverse human Here, we will describe most interesting multi-kinase inhibit among preclinical studies.