Antiangiogenic Therapy Targeting the Tyrosine Kinase Receptor for Vascular Endothelial Growth Factor Receptor Inhibits the Growth of Colon Cancer Liver Metastasis and Induces Tumor and Endothelial Cell Apoptosis
作者： David J. McConkey , Corazon D. Bucana , Wenbiao Liu , Michael R. Wilson , Darren W. Davis
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摘要: Increased vascular endothelial growth factor (VEGF) expression is associated with colon cancer metastases. We hypothesized that inhibition of VEGF receptor activity could inhibit liver BALB/c mice underwent splenic injection CT-26 cells to generate Mice received daily i.p. injections vehicle, tyrosine kinase inhibitor for Flk-1/KDR (SU5416) or VEGF, basic fibroblast factor, and platelet-derived receptors (SU6668). SU5416 SU6668 respectively inhibited metastases (48.1% 55.3%), microvessel formation (42.0% 36.2%), cell proliferation (24.4% 27.3%) increased tumor (by 2.6- 4.3-fold) 18.6- 81.4-fold) apoptosis (P
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Folkman J, The role of angiogenesis in tumor growth. Seminars in Cancer Biology. ,vol. 3, pp. 65- 71 ,(1992)
C H Heldin, Protein tyrosine kinase receptors. Cancer surveys. ,vol. 27, pp. 7- 24 ,(1996)
Corazon D. Bucana, Yasuhiko Kitadai, Karen R. Cleary, Lee M. Ellis, Yutaka Takahashi, Expression of Vascular Endothelial Growth Factor and Its Receptor, KDR, Correlates with Vascularity, Metastasis, and Proliferation of Human Colon Cancer Cancer Research. ,vol. 55, pp. 3964- 3968 ,(1995)
Federico Bussolino, Alberto Mantovani, Graziella Persico, Molecular mechanisms of blood vessel formation Trends in Biochemical Sciences. ,vol. 22, pp. 251- 256 ,(1997) , 10.1016/S0968-0004(97)01074-8
Judah Folkman, Angiogenesis in cancer, vascular, rheumatoid and other disease Nature Medicine. ,vol. 1, pp. 27- 31 ,(1995) , 10.1038/NM0195-27
R Kumar, J Yoneda, C D Bucana, I J Fidler, Regulation of distinct steps of angiogenesis by different angiogenic molecules. International Journal of Oncology. ,vol. 12, pp. 749- 757 ,(1998) , 10.3892/IJO.12.4.749
Lars Holmgren, Michael S. O'Reilly, Judah Folkman, Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Medicine. ,vol. 1, pp. 149- 153 ,(1995) , 10.1038/NM0295-149
Hans-Peter Gerber, Vishva Dixit, Napoleone Ferrara, None, Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells Journal of Biological Chemistry. ,vol. 273, pp. 13313- 13316 ,(1998) , 10.1074/JBC.273.21.13313
Stephen Hsu, Fei Huang, Eileen Friedman, Platelet‐derived growth factor‐B increases colon cancer cell growth in vivo by a paracrine effect Journal of Cellular Physiology. ,vol. 165, pp. 239- 245 ,(1995) , 10.1002/JCP.1041650204
Laura K. Shawver, Kenneth E. Lipson, T. Annie T. Fong, Gerald McMahon, Greg D. Plowman, Laurie M. Strawn, Receptor tyrosine kinases as targets for inhibition of angiogenesis Drug Discovery Today. ,vol. 2, pp. 50- 63 ,(1997) , 10.1016/S1359-6446(96)10053-2