Models for Evaluation of Targeted Therapies of Metastatic Disease

摘要: Metastasis is the most frequent cause of cancer death, and majority therapeutic agents are aimed against systemic disease. Therefore, it surprising that only relatively recently have new therapies been tested with any degree regularity in models mimic metastatic human cancer, even now, truly adjuvant preclinical studies rare. Animal criticized for failing to predict response patients (1). However, growing realization importance cellular context microenvironment, some cases use inappropriate may be misleading results (2,3).