Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer
作者： Chih Jung Chen , Tzu Cheng Su , Chung Min Yeh , Pei Ru Wu , Ming Chung Jiang
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摘要: The Ras-ERK pathway is frequently up-regulated in colorectal cancer. We analyzed the clinical-pathological correlation of K-Ras mutation and phospho-ERK expression mutations were detected only 32.5% (41/126) cancer cases, while all cancers positive for staining. Colorectal with wild-typeK-Ras low had a significantly higher survival rate (log-rank P = 0.04). There 9 cases mutation/low diseases; 88.9% (8/9) them stage III/IV diseases. High was associated high T status cancer, yet combined mutation/phospho-ERK analysis further increased efficiency prognosis. Our results demonstrate that correlated closely progression. Moreover, although has more aggressive phenotype; not very high. Phospho-ERK may be useful marker combination improving prognosis
elsevier.com参考文章(21)
Krzysztof Okoń, Romana Tomaszewska, Agnieszka Klimkowska, Czesław Osuch, Piotr Wójcik, BRAF mutations in sporadic colorectal carcinoma from polish patients. Polish Journal of Pathology. ,vol. 61, pp. 23- 26 ,(2010)
Yixing Jiang, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Hua Cheng, Jaffer A. Ajani, Assessment of K-ras Mutation: A Step Toward Personalized Medicine for Patients With Colorectal Cancer Cancer. ,vol. 115, pp. 3609- 3617 ,(2009) , 10.1002/CNCR.24434
Karoliina Stefanius, Laura Ylitalo, Anne Tuomisto, Rami Kuivila, Tiina Kantola, Päivi Sirniö, Tuomo J Karttunen, Markus J Mäkinen, Frequent mutations of KRAS in addition to BRAF in colorectal serrated adenocarcinoma Histopathology. ,vol. 58, pp. 679- 692 ,(2011) , 10.1111/J.1365-2559.2011.03821.X
V. Adler, M. R. Pincus, P. W. Brandt-Rauf, Z. Ronai, Complexes of p21RAS with JUN N-terminal kinase and JUN proteins. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 10585- 10589 ,(1995) , 10.1073/PNAS.92.23.10585
Chuanshu Huang, Wei-Ya Ma, Jingxia Li, Angela Goranson, Zigang Dong, Requirement of Erk, but not JNK, for arsenite-induced cell transformation. Journal of Biological Chemistry. ,vol. 274, pp. 14595- 14601 ,(1999) , 10.1074/JBC.274.21.14595
Michelle C. Mendoza, E. Emrah Er, John Blenis, The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation Trends in Biochemical Sciences. ,vol. 36, pp. 320- 328 ,(2011) , 10.1016/J.TIBS.2011.03.006
K. J. Schmitz, J. Wohlschlaeger, H. Alakus, J. Bohr, M. A. Stauder, K. Worm, G. Winde, K. W. Schmid, H. A. Baba, Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations. Virchows Archiv. ,vol. 450, pp. 151- 159 ,(2007) , 10.1007/S00428-006-0342-Y
Stéphane Ory, Deborah K. Morrison, Signal transduction: implications for Ras-dependent ERK signaling. Current Biology. ,vol. 14, ,(2004) , 10.1016/J.CUB.2004.03.023
Rika Hoshino, Yuji Chatani, Takao Yamori, Takashi Tsuruo, Hiroya Oka, Osamu Yoshida, Yutaka Shimada, Shigeki Ari-i, Hiromi Wada, Jiro Fujimoto, Michiaki Kohno, Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors Oncogene. ,vol. 18, pp. 813- 822 ,(1999) , 10.1038/SJ.ONC.1202367
E. Castellano, J. Downward, RAS Interaction with PI3K More Than Just Another Effector Pathway Genes & Cancer. ,vol. 2, pp. 261- 274 ,(2011) , 10.1177/1947601911408079