Assessment of K-ras Mutation: A Step Toward Personalized Medicine for Patients With Colorectal Cancer
作者： Yixing Jiang , Eric T. Kimchi , Kevin F. Staveley-O'Carroll , Hua Cheng , Jaffer A. Ajani
DOI: 10.1002/CNCR.24434
关键词:
摘要: … an increasing copy number of EGFR in colorectal cancer by FISH analysis predicted the response to cetuximab. However, tumors with the K-ras mutation did not respond to cetuximab …
sci-hub.se 参考文章(65)
Ping Yuan, APC and K-ras gene mutation in aberrant crypt foci of human colon World Journal of Gastroenterology. ,vol. 7, pp. 352- 356 ,(2001) , 10.3748/WJG.V7.I3.352
Pablo Rodriguez-Viciana, Patricia H. Warne, Ritu Dhand, Bart Vanhaesebroeck, Ivan Gout, Michael J. Fry, Michael D. Waterfield, Julian Downward, PHOSPHATIDYLINOSITOL-3-OH KINASE AS A DIRECT TARGET OF RAS Nature. ,vol. 370, pp. 527- 532 ,(1994) , 10.1038/370527A0
Sjoerd Rodenhuis, Robert J. C. Slebos, Clinical significance of ras oncogene activation in human lung cancer. Cancer Research. ,vol. 52, pp. 2665- 2669 ,(1992)
F. Loupakis, L. Pollina, I. Stasi, G. Masi, N. Funel, M. Scartozzi, I. Petrini, D. Santini, S. Cascinu, A. Falcone, Evaluation of PTEN expression in colorectal cancer (CRC) metastases (mets) and in primary tumors as predictors of activity of cetuximab plus irinotecan treatment Journal of Clinical Oncology. ,vol. 26, pp. 4003- 4003 ,(2008) , 10.1200/JCO.2008.26.15_SUPPL.4003
C. Bokemeyer, I. Bondarenko, J. T. Hartmann, F. G. De Braud, C. Volovat, J. Nippgen, C. Stroh, I. Celik, P. Koralewski, KRAS status and efficacy of first-line treatment of patients with metastatic colorectal cancer (mCRC) with FOLFOX with or without cetuximab: The OPUS experience Journal of Clinical Oncology. ,vol. 26, pp. 4000- 4000 ,(2008) , 10.1200/JCO.2008.26.15_SUPPL.4000
Eric K. Rowinsky, Jolene J. Windle, Daniel D. Von Hoff, Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic Development Journal of Clinical Oncology. ,vol. 17, pp. 3631- 3652 ,(1999) , 10.1200/JCO.1999.17.11.3631
S.J. Leevers, C.J. Marshall, Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein. The EMBO Journal. ,vol. 11, pp. 569- 574 ,(1992) , 10.1002/J.1460-2075.1992.TB05088.X
Eric Van Cutsem, Karen Geboes, The integration of cytotoxics and biologicals in the treatment of metastatic colorectal cancer Best Practice & Research in Clinical Gastroenterology. ,vol. 21, pp. 1089- 1108 ,(2007) , 10.1016/J.BPG.2007.10.020
Kathleen Forrester, Concepcion Almoguera, Kyuhyung Han, William E. Grizzle, Manuel Perucho, Detection of high incidence of K- ras oncogenes during human colon tumorigenesis Nature. ,vol. 327, pp. 298- 303 ,(1987) , 10.1038/327298A0
Scott E Kern, Eric R Fearon, Kasper WF Tersmette, John P Enterline, Mark Leppert, Yusuke Nakamura, Ray White, Bert Vogelstein, Stanley R Hamilton, Allelic Loss in Colorectal Carcinoma JAMA: The Journal of the American Medical Association. ,vol. 261, pp. 3099- 3103 ,(1989) , 10.1001/JAMA.1989.03420210047014