Evaluation of PTEN expression in colorectal cancer (CRC) metastases (mets) and in primary tumors as predictors of activity of cetuximab plus irinotecan treatment
作者： F. Loupakis , L. Pollina , I. Stasi , G. Masi , N. Funel
DOI: 10.1200/JCO.2008.26.15_SUPPL.4003
关键词: Cancer research 、 Suppressor 、 Cetuximab 、 Irinotecan 、 Effector 、 Protein kinase B 、 Colorectal cancer 、 PTEN 、 PI3K/AKT/mTOR pathway 、 Medicine 、 Immunology
摘要: 4003 Background: PTEN is a key tumor suppressor that inactivates PI3K, downstream effector of the EGFR cascade. Mutations resulting in loss lead to uncontrolled activation PI3K/AKT signal...
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